Characteristics of changes in the kallikrein-kinin system of blood in hypertension
Zholob, V.M.; Vygovskiĭ, V.P.; Vinokur, K.I.
Klinicheskaia Meditsina 65(1): 69-73
1987
ISSN/ISBN: 0023-2149 PMID: 3645129 Document Number: 303331
Study of the parameters of the kallikrein-kinin blood system in 317 patients with essential hypertension (I, II, and III stages) has demonstrated that both activation and inhibition of this system can be observed. This is probably associated with different severity of the disease course, the level of arterial pressure during the examination, activity of the pressor systems, and complications. The degree of activation of the kallikrein-kinin system depended on the stage of essential hypertension. Combined therapy with hypotensors, .beta.-adrenergic blocking agents and diuretics, is conducive to the normalization of this system. Kininogenesis increases during treatment of essential hypertension patients when the kallikrein-kinin system is inhibited. A regular decrease of the initially high kinase activity during treatment causes prolonged kinin action. The findings obtained show the important role of the kallikrein-kinin system in the pathogenesis of essential hypertension.