Activity of some hydrolases in mice with transplantable lymphatic leukemia P 388
Sobiech, K.A.; Słowińska, R.; Madej, J.A.; Mazurkiewicz, M.
Folia Histochemica et Cytobiologica 25(1): 61-64
1987
ISSN/ISBN: 0239-8508 PMID: 2887460 Document Number: 303135
Mice-BDF, hybrides, males and aged 3 months were injected intraperitoneally with 104 lymphatic leukemia cells P 388. The mice were killed by bleeding after 2.5 and 10 days after the injection. Gamma-glutamyltransferase (GGT), leucylaminopeptidase (LAP) and cobalt activated acylase activity were determined in the serum of the mice. The inner organs of the animals were verified histopathologically. A statistically significant increase in the activity of the examined enzymes was observed together with the development of transplantable leukemia. These enzymes can be helpful in early monitoring of lymphatic leukemia P 388 in mice.sbd.as markers of cancer growth.