Pulmonary aspergillosis in a case of humoral immunodeficiency
Tinelli, M.; Zambelli, A.; Cavanna, C.; Michelone, G.
Microbiologica 10(2): 235-240
1987
ISSN/ISBN: 0391-5352 PMID: 3587070 Document Number: 302943
A case of recurrent pulmonary aspergillosis in a young girl with common variable hypogammaglobulinaemia and the treatment adopted is described. We employed the plasma-exchange, at the beginning of immunosubstitutive treatment, to provide a high serum concentration of all classes of immunoglobulins and to better control the patient's state of shock. Intravenous immunoglobulins and Amphotericin B were also given in combination with plasma-exchange, having a synergic therapeutic effect. The good condition of the patient, despite the recurrent episodes of fungal pneumonia, suggests that such an approach can lead to long-term, high quality survival in humoral immunodeficient patients.