The genetics of rheumatic disease in man
Goldstein, R.; Arnett, F.C.
Rheumatic Diseases Clinics of North America 13(3): 487-510
1987
ISSN/ISBN: 0889-857X PMID: 3324202 Document Number: 302770
This article reviews the current knowledge of genetic factors conferring susceptibility to several major rheumatic disorders, in particular, rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), systemic lupus erythematosus (SLE), and Sjögren's syndrome. Emphasis is given to major histocompatibility complex associations with these diseases, particularly rapidly evolving knowledge of class II HLA genes and disease-conferring "epitopes." Non-MHC-linked genes, such as T cell receptor and immunoglobulin genes, also may be involved.