Clinical profile and risk factors for oral candidosis in sick newborns
Gupta, P.; Faridi, M.M.; Rawat, S.; Sharma, P.
Indian Pediatrics 33(4): 299-303
1996
ISSN/ISBN: 0019-6061 PMID: 8772904 Document Number: 302587
To provide the clinical profile and assess the significance of various risk factors contributing to the occurrence of oral candidosis in newborns a case-control study was performed in a neonatal intensive care unit (NICU) in Delhi, India. Oral candidosis was documented in 20 of 650 neonates (3.2%) and all cases were treated with local application of 1% clotrimazole. Acute pseudomembranous candidosis was the most common presentation. The mean age of onset was 10.5 d. Candida albicans was the most common isolate (50% of cases) followed by C. tropicalis, C. pseudotropicalis [C. kefyr], C. krusei, C. glabrata [Torulopsis glabrata] and C. parapsilosis. On univariate analysis, male sex, birth asphyxia and prolonged antibiotic therapy had a significant correlation with the occurrence of oral candidosis in neonates. Of these, birth asphyxia was the only factor significantly associated with oral candidosis (P=0.0226) on multivariate analysis.