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Biochemical polymorphic systems in the migrant population of northeastern USSR. VI. Genetic structure of patients in separate nosological groups

Solovenchuk, L.L.

Genetika 23(7): 1311-1318

1987

ISSN/ISBN: 0016-6758
PMID: 3477515
Document Number: 301580
Genotype frequency distribution for a number of polymorphic loci in patients differs significantly in different nosologic groups, in relation to each other and to a sample of healthy individuals. Genetic structure specificity of each nosologic group and different trends of genetic frequency variations, in relation to the sample of healthy individuals, leads to considerable decrease in genetic differences between the united group of pathology and healthy individuals' sample. Spatial differentiation of genetic structure of separate nosologic groups and healthy individuals' sample also confirms genetic isolation of each of these groups and, at the same time, reveals clearly nonspecific biological resistance of human organism.

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