Glycemic and lipid responses to glucomannan in Thais with type 2 diabetes mellitus
Chearskul, S.; Sangurai, S.; Nitiyanant, W.; Kriengsinyos, W.; Kooptiwut, S.; Harindhanavudhi, T.
Journal of the Medical Association of Thailand 90(10): 2150-2157
2007
ISSN/ISBN: 0125-2208 PMID: 18041436 Document Number: 3014
Objective: To evaluate the benefits of glucomannan supplement on glycemic and lipid controls in type 2 diabetic patients.Material and Method. A single-blind, placebo-controlled, crossover trial with two treatments separated by a 2-week washout period was performed in 10 men and 10 women with type 2 diabetes mellitus. Two separated protocols of experiments were sequentially followed Initially, purified glucomannan (I g) or placebo was ingested 30 min before 75-g glucose load to evaluate their effects on glucose absorption and insulin secretion in oral glucose tolerance test (OGTT). Later, the glycemic and livid changes after 4-week intervention with 3 g/day glucomannan comparing to the placebo were determined The standard OGTT was performed before and after ending of each intervention.Results: Glucomannan taken before performing the OGTT can lower the rise of blood glucose and insulin from I to 2 hour in comparison with the placebo, though a statistically significance of insulin was not achieved Long- term glucomannan supplement significantly reduced the 120-min glucose area under the curve of OGTT Glucomannan also decreased the rise of low-density lipoprotein cholesterol (LDL-C). Reductions of HOMA-insulin resistance index and body mass index were detected in glucomannan-treated group though the former was shown only in females. No within- and between-group differences of insulin, ftuctosamine, and other lipids were observed in glucomannan- nor placebo- treated groups.Conclusion: In type 2 diabetes, pre-prandial glucomannan ingestion attenuated a rise of blood glucose without significantly affecting insulin levels. Long-term supplement of glucomannan to the regular diabetic regimen lessened post challenge glucose AUC and impeded the rise of LDL-C. Supplement of glucomannan may be beneficial to the glycemic and lipid controls in type 2 diabetes mellitus.
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