The clinical effect of correction of vitamin E depletion in cystic fibrosis
Kelleher, J.; Miller, M.G.; Littlewood, J.M.; McDonald, A.M.; Losowsky, M.S.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 57(3): 253-259
1987
ISSN/ISBN: 0300-9831 PMID: 3679696 Document Number: 300127
For 18 to 24 months 30 patients with cystic fibrosis, 24 of whom had longstanding low serum vitamin E, were treated with 50 mg alpha -tocopheryl acetate daily. None of the patients received haematinics during the study. Throughout the study the overall clinical state of the patients did not change significantly. Serum vitamin E increased in all patients, but to a variable degree which was not related to the severity of steatorrhoea. Anthropometry, vitamins, essential elements, haemoglobin and albumin, as well as dietary intake and faecal fat excretion, were assessed at the beginning and end of the study. Hb value showed the only significant change, from 13.14 to 13.47 g/100 ml. Of the patients, 21 showed some increase in Hb value; this increase could not be related to clinical state, fat absorption or dietary intake but was related to the improved vitamin E state.