Topical application of human fibroblast interferon (IFN) in cutaneous leishmaniasis
Trau, H.; Schewach-Millet, M.; Shoham, J.; Doerner, T.; Shor, R.; Passwell, J.H.
Israel Journal of Medical Sciences 23(11): 1125-1127
1987
ISSN/ISBN: 0021-2180 PMID: 3325468 Document Number: 299961
Fifteen patients with single or multiple lesions of cutaneous leishmaniasis were randomly assigned to apply either IFN-.beta.-containing cream or a placebo cream base. Despite 8 weeks of therapy no significant improvement of the lesions was achieved. Although topical IFN-.beta. was not effective in this study, several laboratory studies suggest that IFN, particularly IFN-.gamma., may be a therapeutic value in cutaneous leishmaniasis.