Immunotoxicity of chromium compounds: effect of sodium dichromate on the T cell activation in vitro
Kucharz, E.J.; Sierakowski, S.J.
Arhiv Za Higijenu Rada i Toksikologiju 38(3): 239-243
1987
ISSN/ISBN: 0004-1254 PMID: 3502072 Document Number: 298490
Human T cells, isolated from peripheral blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro in the presence of sodium dichromate (10-3 - 10-9 M). A high (10-3 M) concentration of sodium dichromate depressed T cell proliferation whereas low levels of dichromate (10-9 M) led to a significant decrease in interleukin 2 priduction. The results obtained suggest a direct toxic action of sodium dichromate on the functional activity of T cells.