Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines

Iida, M.; Doi, H.; Asamoto, S.; Sugiyama, H.; Sakagami, H.; Kuribayashi, N.; Takeda, M.; Okamura, Y.; Matsumoto, K.

Anticancer Research 19(6b): 5383-5384

1999

ISSN/ISBN: 0250-7005
PMID: 10697565
Document Number: 502487
The relation between the effect of glutathione(GSH)-modulating compounds and platinum compounds (Cisplatin, Nedaplatin)-induced cytotoxicity was investigated. Pretreatment of human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines with L-buthionine-[S,R]-sulfoximine, which decrease the intracellular GSH concentration, remarkably increased their sensitivity against platinum compounds, whereas pretreatment with N-acetyl-L-cysteine, which increase the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of platinum compounds. The results suggest that platinum compounds-induced cytotoxicity can be modified by GSH-modulating compounds in glioblastoma and glioma cell lines.

Document emailed within 1 workday
Secure & encrypted payments

Hannemann, J.; Baumann, K. 1988: Inhibition of lactate-dehydrogenase by cisplatin and other platinum-compounds: enzyme leakage of LDH is not a suitable method to measure platinum-compound-induced kidney cell damage in vitro Research Communications in Chemical Pathology and Pharmacology 60(3): 371-379
Sakagami, H.; Takahashi, H.; Yoshida, H.; Yamamura, M.; Fukuchi, K.; Gomi, K.; Motohashi, N.; Takeda, M. 1995: Induction of DNA fragmentation in human myelogenous leukaemic cell lines by phenothiazine-related compounds Anticancer Research 15(6b): 2533-2540
Moebus, V.J.; Stein, R.; Kieback, D.G.; Runnebaum, I.B.; Sass, G.; Kreienberg, R. 1997: Antitumor activity of new organometallic compounds in human ovarian cancer cell lines and comparison to platin derivatives Anticancer Research 17(2a): 815-821
Chekhun, V.F.; Lukianova, N.Y.; Borikun, T.V.; Zadvorny, T.V.; Mokhir, A. 2017: Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics Experimental Oncology 39(1): 25-29
Wang, J.; Hu, L.; Allalunis-Turner, M.J.; Day, R.S.; Deen, D.F. 1997: Radiation-induced damage in two human glioma cell lines as measured by the nucleoid assay Anticancer Research 17(6d): 4615-4618
Enomoto, H.; Yoshida, J.; Kageyama, N.; Ueda, R.; Kato, T.; Ota, K. 1986: Anti-tumor activity of human recombinant TNF against human malignant glioma cell lines and combined effect with Hu INF-beta Gan to Kagaku Ryoho. Cancer and ChemoTherapy 13(5): 1953-1961
Mao, X.; Kashii, T.; Wang, Q.; Tong, J.; Liu, S. 2000: Studies on cell transformation and cell cycle in human embryo lungs induced by nickel compounds Zhonghua Yu Fang Yi Xue Za Zhi 34(6): 339-341
Kolesova, G.M.; Zakharova, I.A.; Raĭkhman, L.M.; Moshkovskiĭ, I.S. 1979: Effect of platinum and palladium compounds on mitochondrial enzymatic systems Voprosy Meditsinskoi Khimii 25(5): 537-540
Liu, Q.-L.; Wang, Y.-S.; Wang, J.-X. 2009: Effect of insulin on functional status of cord blood-derived dendritic cells and on dendritic cell-induced CTL cytotoxicity against pancreatic cancer cell lines Hepatobiliary and Pancreatic Diseases International: Hbpd Int 8(5): 529-534
De Meio, R.H.; O'Leary, D.J. 1975: Hemolysis by tellurium compounds: telluride and tellurate, effect on reduced glutathione Journal of the American Osteopathic Association 75(4): 430-431
Lin, Z.; Chen, L.; Qiu, Q.; Guo, S. 2016: Isolation and identification of antiproliferative compounds from the roots of Tetrastigma hemsleyanum against MDA-MB-435S cell lines Pakistan Journal of Pharmaceutical Sciences 29(4): 1171-1175
Ali, S.Roohina.; Haque, S.; Mudassar, -.; Versiani, M.Ali.; Faizi, S.; Farooq, A.Dar. 2017: Cytotoxicity and chromosomal aberrations induced by methanolic extract of Cuscuta reflexa and its pure compounds on meristematic cells of Allium species Pakistan Journal of Pharmaceutical Sciences 30(2): 521-529
Hama, S.; Sadatomo, T.; Yoshioka, H.; Kurisu, K.; Tahara, E.; Naruse, I.; Heike, Y.; Saijo, N. 1997: Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation Anticancer Research 17(3c): 1933-1938
Towiańska, A.; Potajałło, U.; Kubica, B. 1986: A study of antiviral action of histamine and its complex derivatives; determination of cytotoxicity of those compounds in cell cultures in vitro on the model of vaccinia Bulletin of the Institute of Maritime and Tropical Medicine in Gdynia 37(1-2): 87-101
Sedo, A.; Malík, R.; Drbal, K.; Lisá, V.; Vlasicová, K.; Mares, V. 2001: Dipeptidyl peptidase IV in two human glioma cell lines European Journal of Histochemistry: Ejh 45(1): 57-63
Bauer, U. 1981: Human exposure to environmental chemicals - investigations on volatile organic halogenated compounds in water, air, food, and human tissues. IV. Communication: calculation of human exposure to organic halogenated compounds from the environment Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. 1. Abt. Originale B Hygiene 174(6): 556-583
Breul, J.; Tief, G.; Hartung, R. 1996: Enhancement of 5-fluorouracil cytotoxicity by folinic acid in different cell-lines of human renal cell carcinoma European Journal of Medical Research 1(7): 339-342
De Meio, R.H.; Onischuk, R.T. 1974: Hemolysis by tellurium compounds: tellurite and tellurate, inhibitors of the hemolysis, effect of in vitro aging of the erythrocytes; and role of sulfhydryl compounds Journal of the American Osteopathic Association 73(8): 653-656
Yan, X.-d.; Pan, L.-y. 2006: Proteomic analysis of human ovarian cancer cell lines and their platinum-resistant clones Zhonghua Fu Chan Ke Za Zhi 41(9): 584-587
Presnov, M.A.; Konovalova, A.L.; Korol'chuk, V.P. 1979: Complex compounds of platinum in the chemotherapy of malignant tumors Vestnik Akademii Meditsinskikh Nauk SSSR 2: 68-80