Experimental colorectal cancer as a model of human disease
Gilbert, J.M.
Annals of the Royal College of Surgeons of England 69(2): 48-53
1987
ISSN/ISBN: 0035-8843 PMID: 3566126 Document Number: 298274
Colorectal cancer may now be induced consistently in experimental animals by the carcinogen 1,2-dimethylhydrazine (DMH). Adenomas and adenocarcinomas are produced in the large bowel and these resemble human colorectal cancer both macroscopically, and in their clinical behaviour. They are a close model of human disease and may be used for the evaluation of anti-cancer therapies and for the development of a diagnostic test for colorectal cancer.
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