Gastrin in the pathogenesis of ulcer disease
Koop, H.
Zeitschrift für Gastroenterologie 25(Suppl 3): 52-55
1987
ISSN/ISBN: 0044-2771 PMID: 3660900 Document Number: 298082
The role of endogenous gastrin in the pathogenesis of "idiopathic" ulcer disease is difficult to determine; however, gastrin is probably only of limited importance besides various probable more important factors. In conditions associated with uncontrolled gastrin production by a gastrin secreting tumor or in cases in which the feedback regulation between gastrin release and intragastric pH is disturbed severe and recurrent ulcers may develop. Radioimmunological determination of serum gastrin levels enable to identify such cases of ulcer disease due to an excess of circulating gastrin.