Hepatotropic action of benzobamil in CCl4 poisoning
Vengerovskiĭ, A.I.; Sedykh, I.M.; Saratikov, A.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(8): 192-195
1987
ISSN/ISBN: 0365-9615 PMID: 3620680 Document Number: 297890
The administration of an antiepileptic drug--benzobamilum-to rats with CCl4-induced hepatitis prevents the development of liver parenchyma necrosis, promotes the retention of normal enzyme activity in hepatocytes, stimulates the excretory and antitoxic liver functions. The drug has antioxidant properties, inhibits the production of lysophosphatidylcholine and the reduction in phosphatidylcholine content in the liver homogenates but fails to intensify CCl4-induced steatosis.