Effects of iodium-heterocycle compound on the thresholds of excitation and fibrillation of the ischemic rabbit myocardium
Cao, W.; Zhao, D.H.; Sheng, B.H.
Yao Xue Xue Bao 22(3): 229-232
1987
ISSN/ISBN: 0513-4870 PMID: 3661212 Document Number: 297879
The effects of #64 iodium-heterocycle (3,6-di--dibenzopyriodonium formate, IHC-64) on the thresholds of excitation and fibrillation of the ischemic rabbit myocardium were investigated. The threshold of excitation and fibrillation was determined as the minimum voltage (MV) required to drive the heart for at least five beats or to induce ventricular fibrillation (VF) separately. IV IHC 64 2 .apprx. 4 mg/kg increased markedly MV to induce VF (p < 0.01), and showed no effect on the excitability. These results suggest that IHC-64 should be of benefit when used in myocardial ischemia.