Relative deconvolution. An explicit method for bioavailability comparison not requiring intravenous administration
Veng-Pedersen, P.; Miller, R.
International Journal of Clinical Pharmacology Therapy and Toxicology 25(1): 10-14
1987
ISSN/ISBN: 0174-4879 PMID: 3557723 Document Number: 297457
A method is presented which enables an explicit evaluation of the relative rate and extent of drug absorption of drug products using an oral drug solution as a reference, thereby avoiding the need for intravenous administration of the drug. The method is demonstrated using data from two sustained release phenylpropanolamine preparations and an oral solution of this drug in a human subject.
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