Cytogenetic analysis of a gossypol-induced murine myxosarcoma
Dhaliwal, M.K.; Norman, J.O.; Pathak, S.; Busbee, D.L.
Journal of the National Cancer Institute 78(6): 1203-1209
1987
ISSN/ISBN: 0027-8874 PMID: 3473256 Document Number: 297419
Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at passage 3 were tumorigenic in syngeneic mice and showed M1, M2, and M3. The presence of M3 has been implicated to be responsible for the tumorigenic phenotype.
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