On the use of anti-sense RNA: down-regulation of mRNA encoding a metalloproteinase inhibitor
Khokha, R.; Denhardt, D.T.
Anticancer Research 7(4a): 653-660
1987
ISSN/ISBN: 0250-7005 PMID: 2444152 Document Number: 297148
In this article we describe methods used for producing anti-sense RNA and the mechanisms by which specific eukaryotic gene functions are inhibited. We also describe some of our studies with plasmid constructs producing anti-sense RNA targeted to a murine metalloproteinase inhibitor and review the evidence for naturally occuring anti-sense transcripts in eukaryotes.
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