Correlation of type A behaviour with adrenergic receptor density: implications for coronary artery disease pathogenesis
Kahn, J.P.; Perumal, A.S.; Gully, R.J.; Smith, T.M.; Cooper, T.B.; Klein, D.F.
Lancet 2(8565): 937-939
1987
ISSN/ISBN: 0140-6736 PMID: 2889863 Document Number: 296465
In 17 healthy young men who had a parent with documented early coronary disease, ratings of type A behaviour correlated with upregulated lymphocyte .beta.2 receptor density and inversely with the ratio of platelet .alpha.2 to lymphocyte .beta.2 receptor density ratio. This indicates a correlation of type A behaviour with receptor-based determinations of increased peripheral .alpha.-adrenergic balance, consistent with increased coronary arterial vasoconstriction, perhaps leading to coronary artery disease.