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Tissue magnesium content in diabetic rats

Wallach, S.; Verch, R.L.

Magnesium 6(6): 302-306

1987

ISSN/ISBN: 0252-1156
PMID: 3448405
Document Number: 296295
Diabetes mellitus is a known cause of hypomagnesemia but soft tissue magnesium depletion has not as yet been demonstrated clinically or experimentally. Direct measurements of soft tissue Mg and calcium in control, streptozotocin (STZ)-diabetic and STZ-insulin-treated-diabetic rats were made and failed to demonstrate consistent decreases in soft tissue Mg content despite the induction of modest hypomagnesemia. In addition, soft tissue Ca content was variably influenced and showed no interrelation with tissue Mg levels. These data do not support the presence of soft tissue Mg depletion nor excessive intracellular Ca uptake in an experimental diabetic model in which modest hypomagnesemia is induced.

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