Acquired deficiencies in antithrombin IIi and C protein during treatment with L-asparaginase
Mielot, F.; Danel, P.; Boyer, C.; Coulombel, L.; Dommergues, J.P.; Tchernia, G.; Larrieu, M.J.
Archives Francaises de Pediatrie 44(3): 161-165
1987
ISSN/ISBN: 0003-9764 PMID: 2883953 Document Number: 296280
Fourteen children treated by L-Asparaginase for acute lymphoblastic leukemia had sequential coagulation studies performed including cephalin-kaolin time, Quick time, fibrinogen, factors II, VII + X and V, as well as antithrombin III and protein C, the major coagulation inhibitors. A severe antithrombin III and protein C deficiency was observed during therapy, with a coexisting hypocoagulability. This equilibrium partially explains the lack of thrombo-embolic phenomena in these children, despite the risk factors present. Although no substitutive therapy was instituted in these cases, their use in high-risk cases is discussed.