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Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase

Millot, F.; Traore, P.; Boinot, C.; Vandermarcq, P.; Sadoun, A.; Brizard, A.; Guilhot, F.

Presse Medicale 30(17): 855-857

2001

ISSN/ISBN: 0755-4982
PMID: 11402939
Document Number: 527020
Cerebral thrombosis associated with protein S deficiency is very rare and is mainly related to hereditary form of protein S deficiency. A 19-year-old girl with acute lymphoblastic leukemia presented hemianopsy within a few days after the first administration of L-asparaginase. Magnetic resonance of the brain showed a cortical infarct. A marked decrease of the level of protein S was documented. Few days later, the patient was free of symptoms and protein S level was restored to the normal suggesting that the cerebral thrombosis was caused by transient protein S deficiency induced by L-asparaginase administration. Patients with neurological complication caused by L-asparaginase should be tested for protein S and other anticoagulant deficiencies.

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