Effects of carbamylcholine on cyclic nucleotide-dependent protein kinase activity in corneal epithelium during resurfacing
Colley, A.M.; Law, M.L.
Metabolic Pediatric and Systemic Ophthalmology 10(3): 73-75
1987
ISSN/ISBN: 0882-889X PMID: 2828819 Document Number: 296238
Nuclear and total cellular cyclic nucleotide-dependent protein kinase activity was assayed in corneal epithelium from carbamylcholine-treated and control eyes of rabbits with and without resurfacing acid burn defects. In epithelium from resurfacing corneas carbamylcholine significantly elevated both nuclear and total cellular cGMP-dependent protein kinase activity and reduced activity of cAMP-dependent protein kinase. The drug also increased the proportion of total cellular cGMP kinase activity represented by nuclear activity, suggesting that the drug may enhance nuclear translocation of cGMP-dependent protein kinase.