A case-control investigation on cancer of the ovary in Bangalore, India
Nandakumar, A.; Anantha, N.; Dhar, M.; Ahuja, V.; Kumar, R.; Reddy, S.; Venugopal, T.; Rajanna; Vinutha, A.T.; Srinivas
International Journal of Cancer 63(3): 361-365
1995
ISSN/ISBN: 0020-7136 PMID: 7591232 DOI: 10.1002/ijc.2910630310Document Number: 295277
Researchers used data from the population-based cancer registry in Bangalore, India, for the period 1982-1985 to conduct a case control study to examine the effect of tobacco, alcohol, dietary practices, and reproductive factors on the development of ovarian cancer. Cases included 97 ever-married women with ovarian cancer. Controls consisted of two sets of age-matched ever-married women living in the same residential area who had no evidence of cancer. A history of practicing family planning was associated with a significant decreased risk of ovarian cancer (odds ratio [OR] = 0.29; p = 0.01). When the researchers considered the family planning method as well as possible confounding factors (e.g., nulliparity, gravidity, and maternal age at first birth), tubectomy reduced the risk of developing ovarian cancer (OR = 0.25; p = 0.02). When they only considered papillary serous cystadenocarcinoma, which accounted for 45.4% of all ovarian cancer cases, the OR was even lower (0.16). The numbers were too small for the other types of ovarian cancer to calculate the OR. Tobacco chewing, alcohol consumption, dietary practices, and other reproductive factors (e.g., parity and maternal age at first birth) did not influence the risk of ovarian cancer. These findings suggest that tubectomy reduces the risk of ovarian cancer. If other studies confirm these findings, perhaps tubectomy can be a preventive measure against ovarian cancer in high-risk nulliparous populations in the West.
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