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Anomalies of cellular immunity in Graves' disease treated by synthetic antithyroid drugs: effects on prognosis

Allannic, H.; Genetet, N.; Edan, G.; Merdrignac, G.; Simon, M.; Genetet, B.

Pathologie-Biologie 35(10): 1333-1338

1987

ISSN/ISBN: 0369-8114
PMID: 2449649
Document Number: 294948
The involvement of humoral immunity mechanism in etiology of Graves' disease was observed for the first time in 1956. Twenty years later cellular auto-immune dysfunction was also described. To day, there is evidence for suppressor T cell deficiency and decrease in T suppressor lymphocytes in Graves' disease and cell mediated immunity might be one of the most important point in the pathogenesis of Graves disease. For the future, cellular auto-immune dysfunction might be used to predict the evolution of the disease and to choice the best therapeutic scheme.

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