Implications of a mathematical model for the role of lymphocytes with different lifespans in the recovery from tolerance
Dolezal, J.; Hraba, T.
Folia Biologica 33(5): 356-362
1987
ISSN/ISBN: 0015-5500 PMID: 2446934 Document Number: 294572
An extension of the mathematical model of immunological tolerance including two categories of B and T helper cells, each having a different lifespan, is presented. The simulated recovery from tolerance is compared with experimental data on B and T helper cell tolerance to human gamma globulin (HGG) induced in adult mice. The performed simulation runs suggest the conclusion that in this case it seems impossible to incorporate a high ratio of both, long-lived B cells and/or short-lived T helper cells, if good agreement with the available experimental data should be preserved.