Inability of fructose 1,6-diphosphate to reduce myocardial infarct size
Brown, E.J.; Erburu, L.; Kloner, R.A.
Journal of Medicine 18(1): 43-53
1987
ISSN/ISBN: 0025-7850 PMID: 3474341 Document Number: 293632
Fructose 1,6-diphosphate has been reported to reduce ischemic damage following coronary artery occlusion. To further evaluate fructose 1,6-diphosphate, we studied its effect on myocardial infarct size in open-chest, anesthetized dogs. Twenty min following left anterior descending coronary artery ligation, the animals received a constant infusion of either normal saline or fructose 1,6-diphosphate. Six hours following coronary artery ligation, the animals were killed and the hearts were sectioned from base to apex. Area at risk, infarct size, and infarct size expressed as a percentage of the area at risk were determined. Fructose 1,6-diphosphate had no effect on the amount of necrosis following coronary artery ligation. The area of necrosis expressed as a percentage of the left ventricle was similar in control (26 +/- 3%) and treated groups (24 +/- 4%). The area of necrosis expressed as a percentage of the area at risk was also similar in control and treated groups. Thus, in this model of myocardial ischemia, fructose 1,6-diphosphate does not reduce myocardial infarct size.