Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal neurons
Henderson, C.E.; Hauser, S.L.; Huchet, M.; Dessi, F.; Hentati, F.; Taguchi, T.; Changeux, J.P.; Fardeau, M.
Neurology 37(8): 1361-1364
1987
ISSN/ISBN: 0028-3878 PMID: 3614658 Document Number: 293528
Preparations derived from embryonic and neonatal chick muscle enhance neurite outgrowth when added to cultures of embryonic chick spinal neurons. In the presence of soluble extracts of biopsied muscle from 15 of 20 patients with spinal muscular atrophy (SMA), the in vitro neurite-promoting activity of neonatal chick muscle was inhibited. There was no comparable inhibition using extracts from 20 age-matched pathologic or morphologically normal controls. The neurite-promoting activity in media conditioned by embryonic myotubes was not inhibited by extracts of the SMA group.