TNF alpha and NRAMP1 polymorphisms in leprosy
Vejbaesya, S.; Mahaisavariya, P.; Luangtrakool, P.; Sermduangprateep, C.
Journal of the Medical Association of Thailand 90(6): 1188-1192
2007
ISSN/ISBN: 0125-2208 PMID: 17624216 Document Number: 2930
Objective: To determine the association of TNF alpha and NRAMP1 polymorphisms in leprosy.Material and Method. The polymorph isms of TNF alpha at -238,-308, and NRAMP1 at INT4, D543N and 3'UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms.Results: The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls.Conclusion: TNF-308A was associated with susceptibility to multibacillary leprosy.
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