Comprehensive examination and treatment on reproductive wastage
Makino, T.; Iizuka, R.
Nihon Sanka Fujinka Gakkai Zasshi 39(7): 1159-1164
1987
ISSN/ISBN: 0300-9165 PMID: 3302074 Document Number: 292257
By the end of March, 1987, 550 couples had been enrolled in the Habitual Miscarriage Outpatient Department at Keio University Hospital in Japan. The average rate of miscarriages during the past 8 years at this hospital was 16.12%. Average number of miscarriages suffered by those couples was 3.09 +- 1.13. Average age of the husband was 34.5 +- 0.3, and that of the wife was 32.8 +- 0.3. All of those who miscarried 2 or 3 times underwent thorough clinical tests. The results showed organic disorders such as uterine myoma (22), arched uterus (16), cervical incompetency (14), double uterus (9), endocrine abnormalities such as hyperthyroidism (6) and hypothyroidism (7), metabolic disorders such as diabetes, rheumatism, and chromosomal abnormality (15/252). In HLA Class II typing, DR antibody was commonly possessed by many couples who had habitual miscarriages. Testings of reproductive wastages both at fertilization and nidation did not yield significant results because of defective methods. Surgical removal of uterine myoma, plastic unification of double uterus, and immunological therapy were among the methods used for treating infertility. Immunotherapy used at Keio University Hospital is as follows: 30 ml venum is taken from the husband aseptically; lymphocyte is isolated from the venum via Ficoll conray; its concentration is adjusted to 3.0-4.0X107/ml; intracutaneous injection of it is given to his wife every 2 - 4 weeks. This therapy resulted in 96 cases of pregnancy among 150 couples. 3 year follow-up study on 42 births show that those babies are healthy and normal in every respect.