Complement and sepsis
Gutiérrez-Fernández, J.; Maroto, M.C.; Piédrola, G.; Zamora, E.
Allergologia et Immunopathologia 15(3): 145-149
1987
ISSN/ISBN: 0301-0546 PMID: 3661354 Document Number: 291810
The present study is an evaluation of changes undergone in the serum of factors C3 and C4 of the complement, IgG, IgA, IgM and circulating immune complexes during the initial phase of sepsis and throughout its development in 53 patients, with the object of establishing their prognostic value. During the initial phase of sepsis the determination of the serum levels of immunoglobulins (IgG, IgA, IgM), C3 and C4 complement components and circulating immune complexes lack prognostic interest. Nevertheless, the disappearance of circulating immune complexes, together with an intensive reduction in concentration of IgG, IgM, and C3 and C4 complement components below the range of normality, during the evolutive course, is an indication of a bad prognosis.