Influence of anesthesia and surgery on postoperative pulmonary complications in peplomycin-treated patients
Mizutani, T.; Fukuda, T.; Kondo, Y.; Nakamura, K.; Yamashita, M.; Naito, H.
Masui. Japanese Journal of Anesthesiology 36(2): 162-167
1987
ISSN/ISBN: 0021-4892 PMID: 2438434 Document Number: 291431
It has been shown in experimental animals that the peplomycin induced pulmonary toxicity is potentiated by oxygen administration. We conducted a retrospective study in the patients treated with peplomycin to examine the influences of oxygen administration and other perioperative management on postoperative pulmonary complications. Nine patients receiving peplomycin preoperatively for treatment of cancer were divided into two groups; a group (n = 5) with low intraoperative FI02 (0.20 to 0.30) and a group (n = 4) with high FI02 (0.30 to 0.35). Except for higher Pao2 in the group with high FI02, there were no significant differences between the two groups in age, total doses of peplomycin, the duration of anesthesia, and the volume of intraoperative fluid administration. No patient of either group developed postoperative pulmonary complications attributable to peplomycin per se and/or intraoperative management including oxygen administration and i.v. infusion. These results suggest that intraoperative administration of oxygen ranging in FI02 from 0.30 to 0.35, together with ordinary fluid management, does not lead to postoperative pulmonary complications in the patients treated with usual doses of peplomycin.