Absence of HL-A homology in couples presenting repeated miscarriages. Trials with multidonor transfusions
Gebuhrer, L.; Mellier, G.; Doillon, M.; Thoulon, J.M.; Bétuel, H.
Revue Francaise de Gynecologie et d'Obstetrique 82(12): 699-703
1987
ISSN/ISBN: 0035-290X PMID: 3432892 Document Number: 291344
Maternal tolerance of the fetus involves maternal immuno-regulating mechanisms. The genetic control of this immune response depends on the HL-A system. An extreme HL-A antigenic community between parents might cause a decreased immune response and increased miscarriages. Contrary to some studies from the literature, in our experience, HL-A homology in couples with recurrent miscarriages does not seem significant. This absence of homology may be explained by an extreme polymorphism of HL-A antigens identified and isolated every year. The role of maternal blocking antibodies in maternal tolerance of the fetus is also discussed. The results of a protocol of multi-donor transfusions in 8 patients, is presented and reviewed according to the resulting pregnancies and data from the literature.