Pneumopathy caused by amiodarone. An often unrecognized iatrogenic entity
Bensaid, J.; Guéret, P.; Blanc, P.; Doumeix, J.J.; Virot, P.; Pinaud, D.; Bontemps, T.; Vergnoux, H.; Leymarie, J.L.; Melloni, B.
Annales de Cardiologie et d'Angeiologie 36(6): 307-312
1987
ISSN/ISBN: 0003-3928 PMID: 3619385 Document Number: 290974
Three cases of interstitial pneumopathy secondary to amiodarone are reported, in addition to almost 200 cases previously published in the literature. The main clinical, radiological, biological and evolutive characteristics are reminded in emphasizing the advantages of bronchioalveolar irrigation. Some factors seem to be predisposing, without any definite proof however. They are: high daily dosage, long term treatment, high cumulative dose, concomitant ingestion of another anti-arrhythmic medication, especially in elderly patients, and in patients who, before any treatment, presented a decreased total pulmonary capacity and a CO transfer capacity lower than 80 p. cent of the theoretical values. Discontinuation of amiodarone and administration of steroids usually produce a rapid regression of the clinical and radiological symptoms.