Effect of starvation on the heptachlor toxicity in rabbits: biochemical changes in blood
Shakoori, A.R.; Haq, R.
Folia Biologica 35(1-2): 33-42
1987
ISSN/ISBN: 0015-5497 PMID: 3609391 Document Number: 290956
Two groups of twelve rabbits each were fed with heptachlor contaminated green fodder for 1 and 2 weeks. Another group of 12 was starved for a week, and then 6 of them were re-fed with normal fodder for a week, whereas the other 6 obtained a heptachlor treated fodder for a week. Blood samples of all these rabbits collected at days 0,7 and 14 were analysed for various haematological and biochemical components. Two weeks of heptachlor treatment caused a significant elevation of the lactate dehydrogenase (LDH) activity and urea content, and a drastic decrease in the total leucocyte count (TLC), alkaline phosphatase (AlP) activity, and bilirubin and protein contents. The one week's treatment had a milder effect: except for a raised total lipid and urea contents, and a decreased TLC and AlP activity, all the other parameters remained unaltered. Administration of heptachlor to starved rabbits increases the glutamate oxaloacetate transaminase (SGOT) and LDH activities, but decreases the TLC, haemoglobin, bilirubin and protein contents and the glutamate pyruvate transaminase activity (SGPT).