Autoantibody to proliferating cell nuclear antigen (PCNA) in SLE: a clinical and serological study
Asero, R.; Origgi, L.; Crespi, S.; Bertetti, E.; D'Agostino, P.; Riboldi, P.
Clinical and Experimental Rheumatology 5(3): 241-246
1987
ISSN/ISBN: 0392-856X PMID: 2892602 Document Number: 290912
In a clinical and serological follow-up study on a large series of subjects with different connective tissue disorders, anti-PCNA/cyclin autoantibodies were found in about 3% of patients with SLE. Positive subjects showed a higher incidence of diffuse proliferative glomerulonephritis and hematological disorders than the general SLE population. A highly significant serological association between PCNA and SL/Ki autoantibodies (p less than 0.001) has been observed. Persistence or disappearance of serum PCNA antibodies were independent of any clinical and serological feature or the therapeutic regimen employed.