Population genetic study of differential fertility in man (illustrated by habitual abortion) . IV. Distribution of blood groups and frequency of incompatible marriages
Kucher, A.N.; Dubrova, I.E.; Kurbatova, O.L.; Altukhov, I.P.
Genetika 23(9): 1671-1683
1987
ISSN/ISBN: 0016-6758 PMID: 3480258 Document Number: 289515
Hereditary variation of 5 immunological systems coded by 8 loci was compared in 148 couples and 100 women with repeated spontaneous abortions in anamnesis (experimental group) and 141 couples and 100 women with normal fertility (control group). Marked differences in distributions of genotypes and frequencies of 3 systems (MNSs, Rhesus, Duffy) and frequency of AB0-incompatible couples were found between control and experimental groups. An average value of observed heterozygosity in experimental group was lower, as compared to the expected value. Possible influence of immunological factors on recurrent fetal wastage is discussed.