Clinical and histologic aspects of chronic delta hepatitis
Viganò, P.; Valsecchi, L.; Morelli, R.; Meraviglia, P.; Cargnel, A.
Bollettino dell'Istituto Sieroterapico Milanese 66(5): 351-356
1987
ISSN/ISBN: 0021-2547 PMID: 3449096 Document Number: 289363
Clinical and histologic valuation of delta chronic hepatitis is performed by a comparison between 46 HDV markers seropositive patients and an analogous group of HBsAg seropositive and delta system negative patients. It is possible to point out of a greater seriousness of clinical and biohumoural situation during a HDV induced disease which is joined up with a more marked histologic damage and a greater inflammatory activity. The presence of specific viral antigen in hepatocyte nucleus suggests a delta-virus direct cytopathic effect.