Prognostic significance of changes in the levels of histamine and other factors in patients with acute cerebral circulatory disorders
Khrapova, E.V.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 87(7): 1013-1016
1987
ISSN/ISBN: 0044-4588 PMID: 3118620 Document Number: 288669
Histamine (H) levels in the cerebrospinal fluid and blood were studied in 95 patients with acute cerebral circulation impairments (ACCI). The results obtained were collated with a number of clinical and biochemical parameters and with some parameters of the gaseous homeostasis. The author used the spectrofluorometric assay of H and serotonin (S) in the biological fluids and was the first to establish an elevation of H levels in the blood and CSF prior to an aggravation of the patient's status, in cases of a remittent course and in protracted hypertensive crises; she also revealed a heterogeneous nature of changes in the blood concentrations of H and S in patients with ACCI, as well as a direct correlation between C concentrations in the blood and pCO2 and an inverse correlation between H levels in the blood and pCO2 levels. It has been demonstrated that in cases of ACCI both H levels, and the H/S ratio and blood gases assessed in combination have prognostic significance. The results obtained have both theoretical and prognostic significance with regard to ACCI research.