Effect of the antiserotoninergic preparation cyproheptadine on the levels of luteinizing and follicle-stimulating hormones and testosterone in patients with polycystic ovaries
Tudose, T.I.
Problemy Endokrinologii 33(3): 22-25
1987
ISSN/ISBN: 0375-9660 PMID: 3116528 Document Number: 288511
An antiserotoninergic drug cyproheptadine was administered to 10 patients at a dose of 4 mg per os to study LH, FSH and testosterone regulation in patients with polycystic ovaries. Blood samples were taken in the morning before, and 1 and 2 h after drug administration. A significant decrease in the level of testosterone (p less than 0.0001) in 1 and 2 h and a tendency to a decrease in the LH level and a LH/FSH ratio in 2 h after cyproheptadine administration were revealed. The effect of the drug on the FSH level was insignificant. A conclusion was made of the involvement of the serotoninergic mechanisms in the regulation of androgenic secretion in patients with polycystic ovaries.