Early and late long-term effects of vasectomy on serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels
Mo, Z.N.; Huang, X.; Zhang, S.C.; Yang, J.R.
Journal of Urology 154(6): 2065-2069
1995
ISSN/ISBN: 0022-5347 PMID: 7500459 DOI: 10.1016/s0022-5347(01)66696-5Document Number: 295044
Purpose: We investigated whether the association between vasectomy and prostate cancer has a hormonal basis. Materials and Methods: We examined serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels by radioimmunoassay on 91 pairs of men who did and did not undergo vasectomy. Results: Men who underwent vasectomy 10 to 19 years previously had higher dihydrotestosterone levels than age matched controls. In men who underwent vasectomy 20 years or more ago testosterone was higher than in corresponding controls. No statistically significant difference in luteinizing hormone and follicle-stimulating hormone levels was noted between the men who had had vasectomy and controls. Conclusions: Our results indirectly support the hypothesis that there is an elevated risk of prostate cancer among men who underwent vasectomy 20 or more years previously.