Phase Ii study of lonidamine in patients with small cell carcinoma of the lung
Murray, N.; Shah, A.; Band, P.
Cancer Treatment Reports 71(12): 1283-1284
1987
ISSN/ISBN: 0361-5960 PMID: 2825992 Document Number: 287914
Lonidamine, a substituted indazole carboxylic acid that inhibits cellular respiration, was given in an escalating oral schedule to 20 evaluable patients with measurable extensive small cell carcinoma of the lung. Two partial responses occurred. Reversible acceptable toxicity included myalgia, nausea, hyperesthesia, photophobia, somnolence, and testicular pain. The drug was not myelosuppressive. Lonidamine has modest activity in small cell lung cancer and further studies are warranted.
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