Inhibition of platelet functions by molsidomine in animals
Just, M.; Martorana, P.A.; Nitz, R.E.
Pathologie-Biologie 35(2 Part 2): 226-228
1987
ISSN/ISBN: 0369-8114 PMID: 3550643 Document Number: 287911
The effect of molsidomine on platelet function has been studied in various experimental models. Molsidomine prevented mortality induced by arachidonic acid as well as thrombocytopenia induced by collagenase, the combination of collagen plus adrenaline, or PAF-acether. Arterial bleeding time was prolonged. Carotid or coronary artery thrombosis and jugular venous thrombosis were inhibited. These effects were obtained in various animal species and were dose-dependent. They suggest the administration of molsidomine for the prevention of thrombotic disorders.