Recent concepts on cerebral ischemia in humans and their implications in therapeutic evaluations
Depresseux, J.C.
Presse Medicale 16(23): 1139-1144
1987
ISSN/ISBN: 0755-4982 PMID: 2955354 Document Number: 287312
Recent concepts concerning focal cerebral ischaemia in man and resulting from the data obtained with positron emission tomography are reported. The evolutive steps in the ischaemic process are divided into: perfusion reserve; extraction reserve recruitment; ischaemic penumbra; lesional process, and post-lesional developments. Circulatory and metabolic patterns corresponding to these evolutive steps are described and illustrated. The potentials of these data as guide-lines in therapeutic trial methodology are discussed.