Bronchial cancers with morphologic and immunohistochemically diversely differentiated metastases
Metz, K.A.; Richter, H.J.; Przybilla, C.; Mann, J.
Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 133(1): 49-54
1987
ISSN/ISBN: 0044-4030 PMID: 2438862 Document Number: 287116
We report on two unusual adenocarcinomas of the lung. The primary of the first case could be classified as a "solid adenocarcinoma" of the lung, whereas the metastases were undifferentiated and contained syncytiotrophoblast-like tumor cells. The primary of the second case consisted of diversely differentiated cells including adenocarcinomatous and syncytiotrophoblast-like cells, while the metastases were either adenocarcinomatous or syncytiotrophoblastic-like differentiated. Immunohistochemically, both primaries showed abundant CEA and little beta-HCG, while the metastases exhibited little CEA and abundant beta-HCG. The implications of such differences between the primaries and their metastases for tumor-cell heterogeneity and tumor classification are discussed.