Localized subepidermal bullae after intravenous phenobarbital
Haroun, M.; Jakubovic, H.R.; Nethercott, J.R.
Cutis 39(3): 233-234
1987
ISSN/ISBN: 0011-4162 PMID: 3103986 Document Number: 287037
The occurrence of subepidermal bullae and sweat gland necrosis in barbiturate-induced coma is well recognized. We report the case of a patient who received intravenous phenobarbital for refractory seizures and subsequently sustained subepidermal bullae without sweat gland necrosis in the skin around and proximal to the intravenous site. Although this may have been secondary to extravasation, a different mechanism of barbiturate-induced bulla formation may exist.