Use of polyacrylate dispersions for nebulization of phenobarbital. 2. in vitro testing of tablets with phenobarbital polyacrylate microspheres
Traue, J.; Kala, H.
Die Pharmazie 39(5): 331-333
1984
ISSN/ISBN: 0031-7144 PMID: 6473494 Document Number: 231429
Using factorial design the authors investigate the qualification of phenobarbital microcapsules with polyacrylate to produce retard tablets. The drug release of the tablets depended significantly on the pressure, the drug concentration and the form of the tablets (microcapsules or corresponding physical mixtures of the ingredients. The drug release from the tablets with microcapsules was more slowly than from tablets with physical mixtures, because there are additional barriers and the formation of a more fixed matrix. The increase of the polyacrylate (from 20 up to 40%) and of the pressure (from 50 up to 100 MPa) inhibits significantly the drug release from the matrices. REM-pictures explain the structure of the tablet surfaces before and after the liberation test.