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Hexamethylene bisacetamide-induced cutaneous vasculitis

Rowinsky, E.K.; McGuire, W.P.; Anhalt, G.J.; Ettinger, D.S.; Donehower, R.C.

Cancer Treatment Reports 71(5): 471-474

1987

ISSN/ISBN: 0361-5960
PMID: 3567971
Document Number: 286532
Nonthrombocytopenic purpura developed in a patient receiving hexamethylene bisacetamide, a tumor-differentiating agent in vitro that is in phase I clinical trials. Histopathological examination revealed features of leukocytoclastic vasculitis with deposition of IgA and complement in the dermal vasculature. Leukocytoclastic vasculitis, an extremely rare complication of therapy with antineoplastic agents, is reported to alert others using this compound of this association.

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