Phase Ii study of mitoxantrone in advanced breast cancer
Ogawa, M.; Kubo, K.; Tominaga, T.; Nomura, Y.; Ota, K.; Yoshida, M.; Taguchi, T.; Hoshino, A.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 13(5): 1980-1984
1986
ISSN/ISBN: 0385-0684 PMID: 3707156 Document Number: 285629
A phase II study of mitoxantrone in cases of advanced breast cancer was conducted by a cooperative study group involving 7 institutions. Mitoxantrone was administered at doses of 10-12 mg/m2 at 3-4-week intervals. A total of 36 patients were entered and 31 were evaluable. There were 4 CRs (13%) and 3 PRs (10%) with an overall response rate of 23% and the durations of responses were between 6 and 25 weeks. Leukopenia was a dose-limiting effect of toxicity and occurred in all patients, while gastrointestinal toxicity and alopecia were mild.