An experimental study on congenital biliary dilatation
Nakashima, Y.
Nihon Geka Hokan. Archiv für Japanische Chirurgie 55(1): 144-170
1986
ISSN/ISBN: 0003-9152 PMID: 3741038 Document Number: 283436
In order to elucidate the effect of the choledochal stenostis on congenital biliary dilation, 123 rats were used and comparisons were made among 5 Groups (Group I: control, Group II: single ligation of the choledochus, Group III: short-term of observation after ligation and dissection of the choledochus, Group IV: long-term observation after ligation and dissection of the choledochus, Group V: cyst-duodenostomy). 1) Cystic dilatation of the choledochus was not induced by single ligation. 2) Cystic dilatation localized in the extrahepatic bile duct could be induced in rats by double ligation and dissection of the choledochus. Cystic dilatation was more pronounced in rats weighing less than 100 g than in those weighing 100 g or more. 3) No cystic dilatation was induced in rats weighing 400 g or more. All these animals died within 3 weeks after ligation and dissection of the choledochus. 4) The intrahepatic bile duct was dilated in any of the rats with induced cystic dilatation. 5) In the histological examination of the dilated bile duct, loss of the epithelium, thickening of the wall, degeneration and destruction of the elastic fiber were observed. These changes resembled the clinical findings. 6) Histological examination of the liver showed marked proliferation of bile ductuli. 7) Necrosis and vacuolization of the liver cells, formation of pseudolobulus and fibrosis observed in the liver Group IV were similar to those in patients with hepatic cirrhosis. 8) No carcinoma was seen in any rats. 9) Cystic dilatation was scarred on observation 7-15 months after ligation and dissection of the choledochus. 10) These results indicate that stenosis of the distal choledochus may be one of the main factors in congenital biliary dilatation, especially cystic type of congenital biliary dilatation.